Bicyclo[2.2.1]heptane-1-methanesulfonic acid, 7,7-dimethyl-2-oxo-, (1S)- → HCID 85074033, compound

HRID 982179Notes

Reaction equation

HRID 982179 reaction equation
[F:1][CH:2]([CH2:17][CH2:18][CH2:19][CH3:20])[C:3](=[O:16])[CH2:4][CH2:5][C@H:6]1[C@H:13]([OH:14])[CH2:12][C@H:11]2[C@@H:7]1[CH2:8][C:9](=[O:15])[O:10]2.[C:21]12(CS(O)(=O)=O)C(C)(C)C(CC1)CC2=O>>[F:1][CH:2]([C:3]1([O:16][CH3:21])[CH2:4][CH2:5][CH:6]2[CH:13]([CH2:12][CH:11]3[CH:7]2[CH2:8][C:9](=[O:15])[O:10]3)[O:14]1)[CH2:17][CH2:18][CH2:19][CH3:20]

Participants

3

Reactant 2

HCID 18462Bicyclo[2.2.1]heptane-1-methanesulfonic acid, 7,7-dimethyl-2-oxo-, (1S)-HCID 14855204HCID 14855204, compound

Product 1

HCID 85074033HCID 85074033, compound

Procedure

According to a similar manner as described in example 4, using (1S,5R,6R,7R)-6-[4(RS)-fluoro-3-oxo-1-octyl]-7-hydroxy-2-oxabicyclo[3.3.0]octane-3-one (0.263 g) and camphor sulfonic acid (0.021 g), the title compound was obtained (yields: 0.236 g, 86%).

Sources & evidence

ORD record
ord-e94b563ec0d341719c944e6be3af0750
Source dataset
uspto-grants-1991_02
Patent number
US04994584

Reaction notes

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