化工社化工社 化学情報印刷レポート · 研究参考用
Thionyl Chloride → 2-Chloro-4,5-difluorobenzoyl chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | Sulfuryl chloride | HCID 24648 | — |
| 反応物 | Phosphorus oxychloride | HCID 24813 | — |
| 反応物 | Phosphorus pentachloride | HCID 24819 | — |
| 反応物 | 2-Chloro-4,5-difluorobenzoic acid | HCID 737171 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 2-Chloro-4,5-difluorobenzoyl chloride | HCID 10198217 | — |
反応手順
In the chlorination of the reaction formula (a), thionyl chloride, sulfuryl chloride, phosphorus pentachloride or phosphorus oxychloride may be used as the chlorinating agents. Among them, thionyl chloride is preferred. The chlorination may be conducted by reacting 2-chloro-4,5-difluorobenzoic acid with the chlorinating agent at a reaction temperature of from 50 ° to 80° C. in an aprotic polar solvent such as DMF, DMSO or dioxane, or without a solvent, followed by isolation by a usual method such as distillation to obtain 2-chloro-4,5-difluorobenzoyl chloride.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04994610 |
| 出典データセット | uspto-grants-1991_02 |
| ORD ID | ord-91470b33749242ecbb88d7dd5e1b1cd5 |
| 出典メモ | uspto-grants-1991_02 |