Acetic Acid → 4'-Hydroxyacetophenone

HRID 982210Notes

Reaction equation

HRID 982210 reaction equation
[C:1]1([OH:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:8](O)(=[O:10])[CH3:9]>>[CH3:9][C:8]([C:4]1[CH:3]=[CH:2][C:1]([OH:7])=[CH:6][CH:5]=1)=[O:10]

Participants

3

Reactant 2

HCID 176Acetic AcidHCID 996Phenol

Product 1

HCID 74694'-Hydroxyacetophenone

Procedure

The same type of reaction is disclosed in U.S. Pat. Nos. 4,560,789 and 4,568,763 in which phenol is reacted with acetic acid in HF to form 4-hydroxyacetophenone.

Workup

  1. customThe same type of reaction

Sources & evidence

ORD record
ord-0814dc7300af4c8cae3555c2e7df83d4
Source dataset
uspto-grants-1991_02
Patent number
US04994623

Reaction notes

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