Isopropenyl acetate → 1-Phenylethanol, (S)-
Reaction equation
C([O:4][C:5]([CH3:7])=[CH2:6])(=O)C.[CH3:8][CH2:9][CH2:10][CH2:11][CH2:12]C>>[C:7]1([C@@H:5]([OH:4])[CH3:6])[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1Participants
3
Conditions
- Temperature
- 25 °C
Procedure
(R, S)-1-Phenylethanol (0.244 gram, 2 mmol) and isopropenyl acetate (0.2 gram, 2 mmol) were dissolved in 10 ml of n-hexane dried in advance on Molecular Sieve 4A for one day. To the resulting solution was added 1 gram of an enzyme (Amano P: Product of Amano Seiyaku K. K.), and the mixture was stirred at 25° C. and 150 r.p.m. for 4 hours. The reaction mixture was filtered, and the filtrate was subjected to HPLC using an optically active column. (S)-1-phenylethanol was obtained in an optical purity of 100% with a theoretical yield of 100%.
Workup
- dry with materialdried in advance on Molecular Sieve 4A for one day
- additionTo the resulting solution was added 1 gram of an enzyme (Amano P: Product of Amano Seiyaku K. K.)
- filtrationThe reaction mixture was filtered
Sources & evidence
- ORD record
- ord-892d98433d1748618e157a91d9914891
- Source dataset
- uspto-grants-1991_02
- Patent number
- US04996158
Reaction notes
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