Hydrochloric Acid → N-[4-(piperidine-4-carbonyl)-phenyl]methanesulfonamide hydrochloride

HRID 982356Notes

Reaction equation

HRID 982356 reaction equation
C([N:4]1[CH2:9][CH2:8][CH:7]([C:10](=[O:22])[C:11]2[CH:16]=[CH:15][C:14]([NH:17][S:18]([CH3:21])(=[O:20])=[O:19])=[CH:13][CH:12]=2)[CH2:6][CH2:5]1)(=O)C.[ClH:23]>>[ClH:23].[CH3:21][S:18]([NH:17][C:14]1[CH:13]=[CH:12][C:11]([C:10]([CH:7]2[CH2:8][CH2:9][NH:4][CH2:5][CH2:6]2)=[O:22])=[CH:16][CH:15]=1)(=[O:19])=[O:20]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 14130038N-[4-[(1-acetyl-4-piperidinyl)carbonyl]phenyl]Methanesulfonamide

Product 1

HCID 14130042N-[4-(piperidine-4-carbonyl)-phenyl]methanesulfonamide hydrochlorideYield 84%

Procedure

43.4 g (0.142 mol) of 1-acetyl-4-(4-methylsulfonylaminobenzoyl)piperidine was suspended in 1 l of 3N hydrochloric acid and the suspension was stirred under reflux for 3 h. After completion of the reaction, the liquid reaction mixture was cooled and white crystals thus formed were filtered, washed with water and dried to obtain 37.8 g (yield: 84%) of the intended compound.

Workup

  1. temperatureunder reflux for 3 h
  2. customAfter completion of the reaction
  3. customthe liquid reaction mixture
  4. temperaturewas cooled
  5. customwhite crystals thus formed
  6. filtrationwere filtered
  7. washwashed with water
  8. customdried

Sources & evidence

ORD record
ord-2b37b54b662c4a20a6161a8784fdff71
Source dataset
uspto-grants-1991_02
Patent number
US04996215

Reaction notes

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