6-(Pyrimidin-5-YL)hex-5-YN-1-OL → 6-(Pyrimidin-5-yl)hexan-1-ol

HRID 982379Notes

Reaction equation

HRID 982379 reaction equation
[N:1]1[CH:6]=[C:5]([C:7]#[C:8][CH2:9][CH2:10][CH2:11][CH2:12][OH:13])[CH:4]=[N:3][CH:2]=1>C(O)C.[Pd]>[N:1]1[CH:6]=[C:5]([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][OH:13])[CH:4]=[N:3][CH:2]=1

Participants

4

Reactant 1

HCID 139997526-(Pyrimidin-5-YL)hex-5-YN-1-OL

Product 1

HCID 135575446-(Pyrimidin-5-yl)hexan-1-olYield 93.9%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent2×

Procedure

A solution of 6-(5-pyrimidinyl)-5-hexynol (3.52 g) in ethanol (20 ml) was added to a pre-hydrogenated suspension of 10% palladium on carbon (1 g) in ethanol (130 ml) and hydrogenated at room temperature and pressure. The mixture was filtered through hyflo and the filtrate evaporated in vacuo to give the title compound as a pale yellow oil (3.38 g).

Workup

  1. filtrationThe mixture was filtered through hyflo
  2. customthe filtrate evaporated in vacuo

Sources & evidence

ORD record
ord-902d94ae0e6f475fb5fb49a5d36508f8
Source dataset
uspto-grants-1991_02
Patent number
US04996218

Reaction notes

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