Benzenemethanol, 4-amino-alpha-(aminomethyl)-3,5-dichloro- → 4-Amino-3,5-dichloro-alpha-[[[6-[[6-(pyrazinyl)hexyl]oxy]hexyl]amino]methyl]benzenemethanol

Participants

Reaction Steps

A solution of 4-amino-α-(aminomethyl)-3,5-dichlorobenzenemethanol (1.2 g), DEA (0.72 ml) and [6-[(6-bromohexyl)oxy]hexyl]pyrazine (1.16 g) in DMF (10 ml) was heated at 100°-110° for 3 h. The resulting dark solution was evaporated in vacuo and the residue purified by FCC eluting with System B (96:2:2→93:5:2) to give the title compound as pale yellow crystals (0.92 g), m.p. 60°-63°.

Provenance & Evidence