反应详情

A solution of 4-amino-α-(aminomethyl)-3,5-dichlorobenzenemethanol (1.2 g), DEA (0.72 ml) and [6-[(6-bromohexyl)oxy]hexyl]pyrazine (1.16 g) in DMF (10 ml) was heated at 100°-110° for 3 h. The resulting dark solution was evaporated in vacuo and the residue purified by FCC eluting with System B (96:2:2→93:5:2) to give the title compound as pale yellow crystals (0.92 g), m.p. 60°-63°.

1. customThe resulting dark solution was evaporated in vacuo
2. customthe residue purified by FCC
3. washeluting with System B (96:2:2→93:5:2)