Sodium Hydroxide → HCID 14651083, compound

HRID 982413Notes

Reaction equation

HRID 982413 reaction equation
[OH-].[Na+].[F:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH2:15][C:14]([CH3:17])([CH3:16])[CH2:13][C:12]([CH3:19])([CH3:18])[C:11]=2/[CH:20]=[CH:21]/[CH:22]([OH:31])[CH2:23][CH:24]([OH:30])[CH2:25][C:26]([O:28]C)=[O:27])=[CH:6][CH:5]=1>C(O)C>[F:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH2:15][C:14]([CH3:17])([CH3:16])[CH2:13][C:12]([CH3:18])([CH3:19])[C:11]=2/[CH:20]=[CH:21]/[CH:22]([OH:31])[CH2:23][CH:24]([OH:30])[CH2:25][C:26]([OH:28])=[O:27])=[CH:6][CH:5]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 14651081HCID 14651081, compound

Product 1

HCID 14651083HCID 14651083, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A 1N NaOH solution (30 ml, 30 mmoles) was added to a solution of the 3,5-dihydroxyester prepared in Step 9 (9.70 g, 24 mmoles) and 60 ml of ethanol. After stirring for 10 minutes, the ethanol was evaporated in vacuo. The residue was redissolved in H2O and extracted twice with ether. The aqueous layer was acidified with 33 ml of 1N HCl and extracted twice with H2CCl2. The H2CCl2 was removed in vacuo.

Workup

  1. customthe ethanol was evaporated in vacuo
  2. dissolutionThe residue was redissolved in H2O
  3. extractionextracted twice with ether
  4. extractionextracted twice with H2CCl2
  5. customThe H2CCl2 was removed in vacuo

Sources & evidence

ORD record
ord-6aa7b6d82de44b69be8f4af1da156251
Source dataset
uspto-grants-1991_02
Patent number
US04996234

Reaction notes

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