1-Bromo-3-chloropropane → HCID 20067710, compound

HRID 982436Notes

Reaction equation

HRID 982436 reaction equation
[C:1]1([C:7]([CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Br[CH2:17][CH2:18][CH2:19][Cl:20]>>[Cl:20][CH2:19][CH2:18][CH2:17][CH:9]([C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1)[C:7]([C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)=[O:8]

Participants

3

Reactant 2

HCID 80061-Bromo-3-chloropropaneHCID 99482-Phenylacetophenone

Product 1

HCID 20067710HCID 20067710, compound

Procedure

The compound is prepared from 19.6 g of desoxybenzoin, which is alkylated with 15.8 g of 3-bromo-1-chloropropane according to the procedure described in Example 17, method 1, except that the reaction time is only 15 min at room temperature. The product is recrystallized from methanol. The yield is 16.6 g (61%) of a product having m.p. 72°-4° C.

Workup

  1. customThe product is recrystallized from methanol

Sources & evidence

ORD record
ord-85e64d0c75644b528c2f5d62e1d4e571
Source dataset
uspto-grants-1991_02
Patent number
US04996225

Reaction notes

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