反应详情

A mixture of 600 mg of 2-[3-hydroxy-4-(3-hydroxypropyl)phenoxy]benzoic acid ethyl ester, 0.4 ml of decyl iodide, and 0.26 g of potassium carbonate in 50 ml of methyl ethyl ketone was stirred at reflux overnight. After cooling to room temperature, the mixture was filtered and the filtrate concentrated in vacuo. Purification of the residue by column chromatography over silica gel eluting with 20% ethyl acetate in hexane provided 510 mg of the desired subtitled intermediate as an oil, MS, IR, NMR.

1. temperatureat reflux overnight
2. filtrationthe mixture was filtered
3. concentrationthe filtrate concentrated in vacuo
4. customPurification of the residue by column chromatography over silica gel eluting with 20% ethyl acetate in hexane