Hydrochloric Acid → 2,3,4,5-Tetrahydro-3-oxo-4-[(pyridin-3-yl)-methyleneamino]-6-methyl-1,2,4-triazinehydrochloride

HRID 982510Notes

Reaction equation

HRID 982510 reaction equation
[O:1]=[C:2]1[N:7]([N:8]=[CH:9][C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)[CH2:6][C:5]([CH3:16])=[N:4][NH:3]1.[ClH:17]>>[ClH:17].[O:1]=[C:2]1[N:7]([N:8]=[CH:9][C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)[CH2:6][C:5]([CH3:16])=[N:4][NH:3]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 863704,5-Dihydro-6-methyl-4-((3-pyridinylmethylene)amino)-1,2,4-triazin-3(2H)-one

Product 1

HCID 679245022,3,4,5-Tetrahydro-3-oxo-4-[(pyridin-3-yl)-methyleneamino]-6-methyl-1,2,4-triazinehydrochloride

Procedure

21.7 g of 2,3,4,5-tetrahydro-3-oxo-4-[(pyridin-3-yl)-methyleneamino]-6-methyl-1,2,4-triazine are dissolved, with heating, in 60 ml of 2N hydrochloride acid. The hot solution is filtered and cooled. The precipitate which crystallises out is isolated by filtration, washed with alcohol and ether and dried in vacuo to give the title compound of formula ##STR32## in the form of a colourless crystal powder; m.p. 240°-241° C. with decomposition; yield: 19 g (75 %).

Workup

  1. filtrationThe hot solution is filtered
  2. temperaturecooled
  3. customThe precipitate which crystallises out
  4. customis isolated by filtration
  5. washwashed with alcohol and ether
  6. customdried in vacuo

Sources & evidence

ORD record
ord-a367a6849efc4413b16a1055a1058d50
Source dataset
uspto-grants-1991_02
Patent number
US04996325

Reaction notes

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