反应详情

4-Chloro-2,6-bis(2-pyridinyl)pyrimidine [prepared by the method of J.A.C.S. 32, 1591 (1967), 4.2 g] piperazine (13.44 g) and ethanol (70 ml) is heated at reflux for 2 hr. The mixture is allowed to cool and the solvent is removed under reduced pressure. The residue is dissolved in chloroform (250 ml), washed with water (twice), dried over sodium sulfate and concentrated under reduced pressure to give an oil. The oil is crystallized from ether to give the title compound, mp 159-161°; MS (m/e) 318 (M+).

1. temperatureat reflux for 2 hr
2. temperatureto cool
3. customthe solvent is removed under reduced pressure
4. dissolutionThe residue is dissolved in chloroform (250 ml)
5. washwashed with water (twice),
6. dry with materialdried over sodium sulfate
7. concentrationconcentrated under reduced pressure
8. customto give an oil
9. customThe oil is crystallized from ether