HCID 54497776, compound → HCID 54511782, compound

HRID 982568Notes

Reaction equation

HRID 982568 reaction equation
[CH2:1]([O:3][C:4](=[O:34])[CH2:5][NH:6][C:7](=[O:33])[C@H:8]([CH2:29][CH:30]([CH3:32])[CH3:31])[NH:9][C:10](=[O:28])[CH:11]([CH2:24][CH:25]([CH3:27])[CH3:26])[CH2:12][N:13]([CH:22]=[O:23])[O:14]CC1C=CC=CC=1)[CH3:2]>C(O)C.[Pd]>[CH2:1]([O:3][C:4](=[O:34])[CH2:5][NH:6][C:7](=[O:33])[C@H:8]([CH2:29][CH:30]([CH3:32])[CH3:31])[NH:9][C:10](=[O:28])[CH:11]([CH2:24][CH:25]([CH3:26])[CH3:27])[CH2:12][N:13]([CH:22]=[O:23])[OH:14])[CH3:2]

Participants

4

Reactant 1

HCID 54497776HCID 54497776, compound

Product 1

HCID 54511782HCID 54511782, compoundYield 98.6%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

0.4 g of [N-formyl-N-benzyloxy 2(RS)-isobutyl-3-aminopropionyl]-L-leucylglycine ethyl ester in 20 ml of ethanol was hydrogenated for 0.75 hour in the presence of 5% palladium/carbon. The mixture was filtered, the filtrate was evaporated and the residue was dried in vacuo to yield 0.32 g (98%) of [N-formyl-N-hydroxy 2(RS)-isobutyl-3-aminopropionyl]-L-leucylglycine ethyl ester as a foam.

Workup

  1. filtrationThe mixture was filtered
  2. customthe filtrate was evaporated
  3. customthe residue was dried in vacuo

Sources & evidence

ORD record
ord-3738db60974b43a8866fb9d7bd0aa02b
Source dataset
uspto-grants-1991_02
Patent number
US04996358

Reaction notes

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