Glycerol → Chlorohexidine

HRID 982573Notes

Reaction equation

HRID 982573 reaction equation
CC(O)=O.CC(O)=O.[CH:9]1[C:10]([NH:16]/[C:17](/[NH2:42])=[N:18]/[C:19](/[NH2:41])=[N:20]/[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26]/[N:27]=[C:28](\[NH2:40])/[N:29]=[C:30](\[NH2:39])/[NH:31][C:32]2[CH:37]=[CH:36][C:35]([Cl:38])=[CH:34][CH:33]=2)=[CH:11][CH:12]=[C:13]([Cl:15])[CH:14]=1.OCC(CO)O>C(O)C.O>[CH:11]1[C:10]([NH:16][C:17]([NH:18][C:19]([NH:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][NH:27][C:28]([NH:29][C:30]([NH:31][C:32]2[CH:37]=[CH:36][C:35]([Cl:38])=[CH:34][CH:33]=2)=[NH:39])=[NH:40])=[NH:41])=[NH:42])=[CH:9][CH:14]=[C:13]([Cl:15])[CH:12]=1

Participants

5

Reactant 2

HCID 753GlycerolHCID 178476578HCID 178476578, compound

Product 1

HCID 178512157Chlorohexidine

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

The formulation was prepared by dissolving 500 mg (0.68 mmol) of lecithin E-80, 125 mg (0.2 mmol) of chlorhexidine diacetate, 120 mg (0.4 mmol) of SLS and 120 mg of Tween-80 in a mixture of 2 ml absolute ethyl alcohol and 3 ml 2-propanediol (propylene glycol) to form a stock solution. The stock solution was diluted with 95 ml of distilled water and 2 g of glycerol was added to form a suspension. The suspension was treated with a high pressure homogenizer (EmulsiFlex® C-5, “Avestin”, Ottawa, Canada), 6 cycles at 12000-15000 psi. The final particle size was about 50 nm with 85% of the drug bound to particles.

Workup

  1. customThe formulation was prepared
  2. customto form a stock solution
  3. additionwas added
  4. customto form a suspension
  5. additionThe suspension was treated with a high pressure homogenizer (EmulsiFlex® C-5, “Avestin”, Ottawa, Canada), 6 cycles at 12000-15000 psi

Sources & evidence

ORD record
ord-4d350b6fdcae4ba3b6e2845ffcfae5dd
Source dataset
uspto-grants-2005_03
Patent number
US06861060B1

Reaction notes

Loading…