Glycerol → Chlorohexidine

Participants

Reaction Steps

The formulation was prepared by dissolving 500 mg (0.68 mmol) of lecithin E-80, 125 mg (0.2 mmol) of chlorhexidine diacetate, 120 mg (0.4 mmol) of SLS and 120 mg of Tween-80 in a mixture of 2 ml absolute ethyl alcohol and 3 ml 2-propanediol (propylene glycol) to form a stock solution. The stock solution was diluted with 95 ml of distilled water and 2 g of glycerol was added to form a suspension. The suspension was treated with a high pressure homogenizer (EmulsiFlex® C-5, “Avestin”, Ottawa, Canada), 6 cycles at 12000-15000 psi. The final particle size was about 50 nm with 85% of the drug bound to particles.

Provenance & Evidence