Hydrochloric Acid → Tiapride Hydrochloride

Participants

Reaction Steps

Two granules are prepared. For granule 1, Methocel® K100M, Avicel® PH102 and tartaric acid are dry-mixed and then granulated with water in a granulating blender and the granules obtained are then dried. The other components, magnesium stearate, Aerosile® 200 and monosodium carbonate are then dry-added and mixed. For granule 2, tiapride hydrochloride, Methocel® and Avicel® are dry-mixed and are then granulated with water in a granulating blender and the granules obtained are then dried. Magnesium stearate and Aerosile® are dry-added and mixed. 3-layer tablets are prepared, containing 250 mg of granule 1 in the first outer layer, 280 mg of granule 2 in the inner layer, which contains 100 mg of base tiapride in hydrochloride form, and 200 mg of granule 1 in the second outer layer.

Provenance & Evidence