反应详情

Two granules are prepared. For granule 1, Methocel® K100M, Avicel® PH102 and tartaric acid are dry-mixed and then granulated with water in a granulating blender and the granules obtained are then dried. The other components, magnesium stearate, Aerosile® 200 and monosodium carbonate are then dry-added and mixed. For granule 2, tiapride hydrochloride, Methocel® and Avicel® are dry-mixed and are then granulated with water in a granulating blender and the granules obtained are then dried. Magnesium stearate and Aerosile® are dry-added and mixed. 3-layer tablets are prepared, containing 250 mg of granule 1 in the first outer layer, 280 mg of granule 2 in the inner layer, which contains 100 mg of base tiapride in hydrochloride form, and 200 mg of granule 1 in the second outer layer.

1. customTwo granules are prepared
2. customthe granules obtained
3. customare then dried
4. additionThe other components, magnesium stearate, Aerosile® 200 and monosodium carbonate are then dry-added
5. additionmixed
6. additionFor granule 2, tiapride hydrochloride, Methocel® and Avicel® are dry-mixed
7. customthe granules obtained
8. customare then dried
9. additionMagnesium stearate and Aerosile® are dry-added
10. additionmixed
11. custom3-layer tablets are prepared
12. additioncontaining 250 mg of granule 1 in the first outer layer, 280 mg of granule 2 in the inner layer, which