Hydroxyamine hydrochloride → HCID 178455673, compound

HRID 982591Notes

Reaction equation

HRID 982591 reaction equation
Cl.N[OH:3].C[N:5]([CH:7]=[N:8][C:9]1[N:14]=[C:13]([C:15]([F:18])([CH3:17])[CH3:16])[N:12]=[C:11]([NH:19][CH:20]([CH:30]2[CH2:32][CH2:31]2)[CH2:21][CH2:22][CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[N:10]=1)C>CO>[F:18][C:15]([C:13]1[N:12]=[C:11]([NH:19][CH:20]([CH:30]2[CH2:32][CH2:31]2)[CH2:21][CH2:22][CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[N:10]=[C:9]([NH:8][CH:7]=[N:5][OH:3])[N:14]=1)([CH3:17])[CH3:16]

Participants

4

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 69736561HCID 69736561, compound

Product 1

HCID 178455673HCID 178455673, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

0.69 g (10 mmol) of hydroxylamine hydrochloride are added with stirring at room temperature to a solution of 1.99 g (5 mmol) of 2-dimethylaminomethyleneamino-4-(1-fluoro-1-methylethyl)-6-(1cyclopropyl-4-phenyl-1-butylamino) -1,3,5-triazine in 20 ml of methanol. The reaction mixture is stirred for 2 hours at room temperature. All volatile constituents are carefully distilled off. The crude product is taken up in methylene chloride. The mixture is washed with water, dried over Na2SO4 and evaporated in vacuo. This gives 1.81 g (93.7% of theory) of N-[4-(1-fluoro -1-methylethyl)-6-(1-cyclopropyl-4-phenyl-1-butylamino)-1,3,5-triazin-1-yl]formamide oxime as pale yellow oil.

Workup

  1. distillationAll volatile constituents are carefully distilled off
  2. washThe mixture is washed with water
  3. dry with materialdried over Na2SO4
  4. customevaporated in vacuo

Sources & evidence

ORD record
ord-ad7cf574c47f4eaeb909f38a69406c78
Source dataset
uspto-grants-2005_03
Patent number
US06861389B2

Reaction notes

Loading…