1-Methylpiperazine → 2-(4-chlorocinnamyl)-6-(3-fluoro-4-methoxyphenyl)-4-(4-methyl-1-piperazinyl)methyl-2H-pyridazin-3-one

HRID 982808Notes

Reaction equation

HRID 982808 reaction equation
[Cl:1][C:2]1[CH:32]=[CH:31][C:5]([CH:6]=[CH:7][CH2:8][N:9]2[C:14](=[O:15])[C:13]([CH2:16]OS(C)(=O)=O)=[CH:12][C:11]([C:22]3[CH:27]=[CH:26][C:25]([O:28][CH3:29])=[C:24]([F:30])[CH:23]=3)=[N:10]2)=[CH:4][CH:3]=1.[CH3:33][N:34]1[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:6]=[CH:7][CH2:8][N:9]2[C:14](=[O:15])[C:13]([CH2:16][N:37]3[CH2:38][CH2:39][N:34]([CH3:33])[CH2:35][CH2:36]3)=[CH:12][C:11]([C:22]3[CH:27]=[CH:26][C:25]([O:28][CH3:29])=[C:24]([F:30])[CH:23]=3)=[N:10]2)=[CH:31][CH:32]=1

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 738582842-(4-chlorocinnamyl)-6-(3-fluoro-4-methoxyphenyl)-4-methane sulfonyloxymethyl-2H-pyridazin-3-one

Product 1

HCID 672132142-(4-chlorocinnamyl)-6-(3-fluoro-4-methoxyphenyl)-4-(4-methyl-1-piperazinyl)methyl-2H-pyridazin-3-oneYield 66.3%

Procedure

Following the procedure of Example 1(10), 2-(4-chlorocinnamyl)-6-(3-fluoro-4-methoxyphenyl)-4-methanesulfonyloxymethyl-2H-pyridazin-3-one and 1-methylpiperazine were reacted to yield the title compound as pale brown neeldes (yield: 66.3%).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-db2d795c82bf4dc791eeef047773c996
Source dataset
uspto-grants-2005_03
Patent number
US06861428B2

Reaction notes

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