反应详情

Racemic 2-benzhydryl-3-quinuclidinone (52.45 g, 180 mmol) was dissolved in denatured ethanol (525 ml) with acetic acid (10.4 ml, 180 mmol) and L-tartaric acid (27 g, 180 mmol) was added. The mixture was heated to reflux for 12 hours and then allowed to cool to room temperature and held for one hour. The solids were collected and dried under vacuum at 40° C. for 12 hours. The yield of the desired salt was 69.9 g, 88% of theory.

1. additionwas added
2. temperatureThe mixture was heated
3. temperatureto reflux for 12 hours
4. customThe solids were collected
5. customdried under vacuum at 40° C. for 12 hours