反应详情

To a suspension of LAH (276 mg, 7.2 mmol) in THF (20 mL) under nitrogen at rt was added dropwise a solution of 2-[3-(1H-indol-4-yl)-phenyl]-N,N-dimethyl-acetamide (500 mg, 1.8 mmol) in THF (10 mL). After stirring at rt for 6 hours, the reaction was quenched with water (0.6 mL) dropwise. The precipitate was filtered off, washed with ethyl acetate (3×), the filtrate was concentrated t give 640 mg of {2-[3-(1H-indol-4-yl)-phenyl)-ethyl}-dimethyl-amine.

1. customthe reaction was quenched with water (0.6 mL) dropwise
2. filtrationThe precipitate was filtered off
3. washwashed with ethyl acetate (3×)
4. concentrationthe filtrate was concentrated