Piperidine → HCID 60061481, compound

HRID 983172Notes

Reaction equation

HRID 983172 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:17]=[CH:16][CH:15]=[C:14]3[C:10]=2[CH2:11][C:12](=[O:18])[NH:13]3)[CH:5]=[C:6]([F:8])[CH:7]=1.[OH:19][CH:20]([CH2:33][N:34]1[CH2:38][CH2:37][CH2:36][CH2:35]1)[CH2:21][NH:22][C:23]([C:25]1[CH:29]=[C:28]([CH3:30])[NH:27][C:26]=1[CH:31]=O)=[O:24].N1CCCCC1>C(O)C>[OH:19][CH:20]([CH2:33][N:34]1[CH2:35][CH2:36][CH2:37][CH2:38]1)[CH2:21][NH:22][C:23]([C:25]1[CH:29]=[C:28]([CH3:30])[NH:27][C:26]=1/[CH:31]=[C:11]1\[C:12](=[O:18])[NH:13][C:14]2[C:10]\1=[C:9]([C:4]1[CH:3]=[C:2]([F:1])[CH:7]=[C:6]([F:8])[CH:5]=1)[CH:17]=[CH:16][CH:15]=2)=[O:24]

Participants

5

Reactant 3

HCID 8082PiperidineHCID 22561787HCID 22561787, compoundHCID 91556839HCID 91556839, compound

Product 1

HCID 60061481HCID 60061481, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4-(3,5-Difluoro-phenyl)-1,3-dihydro-indol-2-one (73.5 mg, 0.3 mmol) was condensed with 2-formyl-5-methyl-1H-pyrrole-3-carboxylic acid (2-hydroxy-3-pyrrolidin-1-yl-propyl)-amide (excess) and piperidine in ethanol to give 40 mg of the titled compound as a yellow solid.

Sources & evidence

ORD record
ord-31f783fa4f604b9cbf967166b4fcd69b
Source dataset
uspto-grants-2005_03
Patent number
US06861418B2

Reaction notes

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