m-Tolylacetic acid → N-[(3-methylphenyl)acetyl]alanine Iso-butyl Ester

HRID 983227Notes

Reaction equation

HRID 983227 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([OH:11])=O)[CH:5]=[CH:6][CH:7]=1.[CH2:12]([O:16][C:17](=[O:21])[C@H:18]([CH3:20])[NH2:19])[CH:13]([CH3:15])[CH3:14]>>[CH2:12]([O:16][C:17](=[O:21])[C@H:18]([CH3:20])[NH:19][C:9](=[O:11])[CH2:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([CH3:1])[CH:3]=1)[CH:13]([CH3:15])[CH3:14]

Participants

3

Reactant 2

HCID 12121m-Tolylacetic acidHCID 137435562-methylpropyl (2S)-2-aminopropanoate

Product 1

HCID 53803690N-[(3-methylphenyl)acetyl]alanine Iso-butyl Ester

Procedure

Following General Procedure I′ above, and using 3-methylphenylacetic acid (Aldrich) and alanine iso-butyl ester (prepared following General Procedure J′ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-244b076629cd443fa79edb7fd2a3ad61
Source dataset
uspto-grants-2005_03
Patent number
US06861558B2

Reaction notes

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