Ethyl formate → HCID 7073861, compound

HRID 983251Notes

Reaction equation

HRID 983251 reaction equation
[CH3:1][C@H:2]([NH2:9])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[CH:10](OCC)=[O:11]>>[CH3:1][C@H:2]([NH:9][CH:10]=[O:11])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 8025Ethyl formateHCID 758181-Phenethylamine, (-)-

Product 1

HCID 7073861HCID 7073861, compound

Conditions

Temperature
55 °C

Procedure

(S)-(−)-α-Methylbenzylamine (1 molar eq.) was treated with ethyl formate (80 molar eq.; Aldrich). A precipitate formed immediately. The suspension was heated to reflux (55° C.) for 3 hours. The precipitate went into solution upon heating. The solution was cooled to ambient temperature and concentrated via rotary evaporation. The resultant solid was used without purification.

Workup

  1. customA precipitate formed immediately
  2. temperatureThe suspension was heated
  3. temperatureupon heating
  4. temperatureThe solution was cooled to ambient temperature
  5. concentrationconcentrated via rotary evaporation
  6. customThe resultant solid was used without purification

Sources & evidence

ORD record
ord-36460ecebecd4778a9ab28892815505d
Source dataset
uspto-grants-2005_03
Patent number
US06861558B2

Reaction notes

Loading…