3-Iodoaniline → HCID 22559497, compound

HRID 983351Notes

Reaction equation

HRID 983351 reaction equation
[N+](C1C=CC([N:10]([C:14]2[S:15][C:16]([CH:19]([CH3:21])[CH3:20])=[CH:17][N:18]=2)[C:11](=[O:13])[O-])=CC=1)([O-])=O.[I:22][C:23]1[CH:24]=[C:25]([CH:27]=[CH:28][CH:29]=1)[NH2:26]>C(#N)C>[CH:19]([C:16]1[S:15][C:14]([NH:10][C:11]([NH:26][C:25]2[CH:27]=[CH:28][CH:29]=[C:23]([I:22])[CH:24]=2)=[O:13])=[N:18][CH:17]=1)([CH3:20])[CH3:21]

Participants

4

Reactant 2

HCID 122713-IodoanilineHCID 69732194HCID 69732194, compound

Product 1

HCID 22559497HCID 22559497, compoundYield 73.3%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
70 °C

Procedure

1 g (3.25 mmol) of 4-nitrophenyl-5-isopropyl-1,3-thiazol-2-ylcarbamate and 0.39 ml (3.25 mmol) of 3-iodoaniline were suspended under argon in 25 ml of acetonitrile. After 2 hours at 70° C. the resulting solution was cooled, giving rise 0.923 g of the title compound, recrystallized from a mixture of diethylether/pentane 1/1.

Sources & evidence

ORD record
ord-93ad13622d754342b5a429c586cd3a85
Source dataset
uspto-grants-2005_03
Patent number
US06863647B2

Reaction notes

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