反应详情

A solution of 2-bromo-3-methoxy-pyridine from Example 13a in DMSO is treated with NaCN at 120° C. for 18 h. The reaction mixture is evaporated, the residue is taken into ethyl acetate, washed with 5% Na2CO3 (aqueous), dried over MgSO4 and evaporated to give 3-methoxy-pyridine-2-carbonitrile.

1. customThe reaction mixture is evaporated
2. washwashed with 5% Na2CO3 (aqueous)
3. dry with materialdried over MgSO4
4. customevaporated