HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Cyanide → 3-Methoxypyridine-2-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Cyanide | HCID 8929 | — |
| Reactant | 2-Bromo-3-methoxypyridine | HCID 90364 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 3-Methoxypyridine-2-carbonitrile | HCID 11332493 | — |
Reaction Steps
A solution of 2-bromo-3-methoxy-pyridine from Example 13a in DMSO is treated with NaCN at 120° C. for 18 h. The reaction mixture is evaporated, the residue is taken into ethyl acetate, washed with 5% Na2CO3 (aqueous), dried over MgSO4 and evaporated to give 3-methoxy-pyridine-2-carbonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06864267B2 |
| Source dataset | uspto-grants-2005_03 |
| ORD ID | ord-502faba2f974483ca1961d2bb4780eec |
| Source note | uspto-grants-2005_03 |