反应详情

A solution of 3-methoxy-pyridine-2-carbonitrile from Example 13b in CCl4 is treated with N-bromosuccinimide (1 equiv.) and catalytic 2,2-azobisisobutyronitrile and is heated at reflux for 18 h. The reaction mixture is evaporated, the residue is taken into ethyl acetate, washed with 5% Na2CO3 (aqueous), 5 % Na2S2O3 (aqueous), dried over MgSO4 and evaporated to give 6-bromo-3-methoxy-pyridine-2-carbonitrile.

1. temperatureis heated
2. temperatureat reflux for 18 h
3. customThe reaction mixture is evaporated
4. washwashed with 5% Na2CO3 (aqueous), 5 % Na2S2O3 (aqueous)
5. dry with materialdried over MgSO4
6. customevaporated