HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-bromobutanimide → 6-Bromo-3-methoxypicolinonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 3-Methoxypyridine-2-carbonitrile | HCID 11332493 | — |
| Solvent | Carbon Tetrachloride | HCID 5943 | — |
| Product | 6-Bromo-3-methoxypicolinonitrile | HCID 22560740 | — |
Reaction Steps
A solution of 3-methoxy-pyridine-2-carbonitrile from Example 13b in CCl4 is treated with N-bromosuccinimide (1 equiv.) and catalytic 2,2-azobisisobutyronitrile and is heated at reflux for 18 h. The reaction mixture is evaporated, the residue is taken into ethyl acetate, washed with 5% Na2CO3 (aqueous), 5 % Na2S2O3 (aqueous), dried over MgSO4 and evaporated to give 6-bromo-3-methoxy-pyridine-2-carbonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06864267B2 |
| Source dataset | uspto-grants-2005_03 |
| ORD ID | ord-bcbb2527f67f4b7eaece1a3c9a9dd2c5 |
| Source note | uspto-grants-2005_03 |