Potassium Carbonate → HCID 22028112, compound

HRID 983438Notes

Reaction equation

HRID 983438 reaction equation
Cl[C:2]1[N:7]=[C:6]([Cl:8])[N:5]=[CH:4][N:3]=1.[C:9]([O-])([O-])=O.[K+].[K+].C[NH:16][C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([Cl:23])[CH:18]=1>C(C#N)(C)=O>[CH3:9][N:5]1[CH:4]=[N:3][C:2]([NH:16][C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([Cl:23])[CH:18]=2)=[N:7][CH:6]1[Cl:8]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 178102,4-Dichloro-1,3,5-triazineHCID 1389003-chloro-N-methylaniline

Product 1

HCID 22028112HCID 22028112, compound

Reagents, catalysts & solvents 1

HCID 694302-OxopropiononitrileSolvent

Conditions

Temperature
0 °C

Procedure

A mixture of the compound 2,4-dichloro-1,3,5-triazine (2.5 g, 16.7 mmol) and solid K2CO3 (6.9 g, 49.9 mmol) was suspended in AcCN (50 mL) under nitrogen at 0° C. followed by addition of N-methyl-3-chloroaniline (2.5 g, 17.7 mmol). The mixture was stirred at 0° C. for 2 h. The reaction was quenched by pouring onto ice/water. The white solid formed was collected by suction filtration and dried under vacuum to give N-methyl-2-chloro-4-(3-chloroanilino)-1,3,5-triazine. MS m/z=256. Calc'd for C10H8Cl2N4: 254.01.

Workup

  1. customThe reaction was quenched
  2. additionby pouring onto ice/water
  3. customThe white solid formed
  4. filtrationwas collected by suction filtration
  5. customdried under vacuum

Sources & evidence

ORD record
ord-44e1bebff25a4f6aa2830230b2110ecb
Source dataset
uspto-grants-2005_03
Patent number
US06864255B2

Reaction notes

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