反应详情

温度

115 °C

A mixture of [4-(2-chloro-benzimidazol-1-yl)-[1,3,5]triazin-2-yl]-(3,4,5-trimethoxy-phenyl)amine (Example 1, step 1)(41 mg, 0.10 mmol), 3-aminobenzamide (14 mg, 0.10 mmol) and DIEA (16 mg, 0.12 mmol) in IpOH (3.5 mL) was heated at 100-130° C. for 10-40 h. On cooling a precipitate formed which was collected, washed with IpOH, ether and dried to give 3-{1-[4-(3,4,5-trimethoxy-phenylamino)-[1,3,5]triazin-2-yl]-1H-benzoimidazol-2-ylamino}-benzamide as a yellow solid.

1. temperatureOn cooling a precipitate
2. customformed which
3. customwas collected
4. washwashed with IpOH, ether
5. customdried