反应详情

温度

65 °C

To a suspension of (4-chloro-[1,3,5]triazin-2-yl)-(3,4,5-trimethoxy-phenyl)amine (2.97 g, 10 mmol) and 2-chlorobenzimidazole (1.53 g, 10 mmol) in dry AcCN (100 mL) was added ground K2CO3 (1.68 g, 12 mmol). The resulting mixture was heated at 65° C. for 4 h, cooled to RT, concentrated in vacuo and purified by column chromatography (EtOAc/n-Hexanes) to provide [4-(2-chloro-benzimidazol-1-yl)-[1,3,5]triazin-2-yl]-(3,4,5-trimethoxy-phenyl)amine as a white powder. MS m/z 413=[M+H]+. Calc'd for C19H17ClN6O3: 412.11:

1. temperaturecooled to RT
2. concentrationconcentrated in vacuo
3. custompurified by column chromatography (EtOAc/n-Hexanes)