Glutathione → Formaldehyde

HRID 983761Notes

Reaction equation

HRID 983761 reaction equation
[NH2:1][C@@H:2]([CH2:6][CH2:7][C:8]([NH:10][C@H:11]([C:14]([NH:16][CH2:17][C:18]([OH:20])=[O:19])=[O:15])[CH2:12][SH:13])=[O:9])[C:3]([OH:5])=[O:4].[CH:21](SC[C@@H](C(NCC(O)=O)=O)NC(=O)CC[C@@H](C(O)=O)N)=[O:22].OCSC[C@@H](C(NCC(O)=O)=O)NC(=O)CC[C@@H](C(O)=O)N>>[NH2:1][C@@H:2]([CH2:6][CH2:7][C:8]([NH:10][C@H:11]([C:14]([NH:16][CH2:17][C:18]([OH:20])=[O:19])=[O:15])[CH2:12][SH:13])=[O:9])[C:3]([OH:5])=[O:4].[CH2:21]=[O:22]

Participants

5

Reactant 3

HCID 124886GlutathioneHCID 1891225-({1-[(Carboxymethyl)imino]-3-(formylsulfanyl)-1-hydroxypropan-2-yl}imino)-5-hydroxynorvalineHCID 447123L-γ-Glutamyl-S-(hydroxymethyl)-L-cysteinylglycine

Product 2

HCID 712FormaldehydeHCID 124886Glutathione

Procedure

To be exact, the glutathione-dependent formaldehyde dehydrogenase (EC 1.2.1.1) used in the present invention is an enzyme reversibly catalyzes the production of S-formylglutathione and reduced coenzyme in the presence of oxidized coenzyme, using, as a substrate, S-hydroxylmethylglutathione non-enzymatically produced from glutathione and formaldehyde.

Sources & evidence

ORD record
ord-8ef0eaa61b114f37aee8bae76f46fbea
Source dataset
uspto-grants-2005_03
Patent number
US06867012B2

Reaction notes

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