Potassium Hydroxide → HCID 22556916, compound

Participants

Reaction Steps

5-Chloro-2-methoxy-3′-nitro-biphenyl-3-carboxylic acid methyl ester 43 (0.59 g, 1.8 mmol) is dissolved in THF (1.8 mL) and treated with a solution of 2 N methanolic KOH (1.8 mL, 3.7 mmol). After 16 h, the solvent is removed under reduced pressure, followed by dilution with 5 mL of 1 M HCl and 10 mL of ice cold water. The resulting precipitate is isolated by filtration, rinsed with water and dried yielding 5-Chloro-2-methoxy-3′-nitro-biphenyl-3-carboxylic acid 44

Provenance & Evidence