Potassium Hydroxide → HCID 22556916, compound

HRID 983793Notes

Reaction equation

HRID 983793 reaction equation
C[O:2][C:3]([C:5]1[C:6]([O:21][CH3:22])=[C:7]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([N+:18]([O-:20])=[O:19])[CH:13]=2)[CH:8]=[C:9]([Cl:11])[CH:10]=1)=[O:4].[OH-].[K+]>C1COCC1>[Cl:11][C:9]1[CH:10]=[C:5]([C:3]([OH:4])=[O:2])[C:6]([O:21][CH3:22])=[C:7]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([N+:18]([O-:20])=[O:19])[CH:13]=2)[CH:8]=1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 57143370HCID 57143370, compound

Product 1

HCID 22556916HCID 22556916, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

5-Chloro-2-methoxy-3′-nitro-biphenyl-3-carboxylic acid methyl ester 43 (0.59 g, 1.8 mmol) is dissolved in THF (1.8 mL) and treated with a solution of 2 N methanolic KOH (1.8 mL, 3.7 mmol). After 16 h, the solvent is removed under reduced pressure, followed by dilution with 5 mL of 1 M HCl and 10 mL of ice cold water. The resulting precipitate is isolated by filtration, rinsed with water and dried yielding 5-Chloro-2-methoxy-3′-nitro-biphenyl-3-carboxylic acid 44

Workup

  1. customthe solvent is removed under reduced pressure
  2. customThe resulting precipitate is isolated by filtration
  3. washrinsed with water
  4. customdried

Sources & evidence

ORD record
ord-cd8f938b7535496fa069f98f121e818c
Source dataset
uspto-grants-2005_03
Patent number
US06867200B1

Reaction notes

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