2,4-Dichlorobenzylidenemalononitrile → 5-Aminomethyl-6-(2,4-dichloro-phenyl)-2-naphthalen-1-yl-pyrimidin-4-ylamine

HRID 983861Notes

Reaction equation

HRID 983861 reaction equation
[C:1]1([C:11]([NH2:13])=[NH:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[Cl:14][C:15]1[CH:26]=[C:25]([Cl:27])[CH:24]=[CH:23][C:16]=1[CH:17]=[C:18]([C:21]#[N:22])[C:19]#[N:20]>>[NH2:22][CH2:21][C:18]1[C:19]([NH2:20])=[N:12][C:11]([C:1]2[C:10]3[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=3)[CH:4]=[CH:3][CH:2]=2)=[N:13][C:17]=1[C:16]1[CH:23]=[CH:24][C:25]([Cl:27])=[CH:26][C:15]=1[Cl:14]

Participants

3

Reactant 2

HCID 180892,4-DichlorobenzylidenemalononitrileHCID 12301251Naphthalene-1-carboxamidine

Product 1

HCID 101728945-Aminomethyl-6-(2,4-dichloro-phenyl)-2-naphthalen-1-yl-pyrimidin-4-ylamine

Procedure

The title compound, MS: m/e=395.3 (M+H+), was prepared from naphthalene-1-carboxamidine and 2-(2,4-dichloro-benzylidene)-malononitrile in analogy to the process described in Example 11 as a solid.

Sources & evidence

ORD record
ord-e215e16c692c4a35b04a5886e11de604
Source dataset
uspto-grants-2005_03
Patent number
US06867205B2

Reaction notes

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