HCID 10268826, compound → HCID 9814705, compound

HRID 983912Notes

Reaction equation

HRID 983912 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:15]3[C:11]([S:12][CH2:13][CH2:14]3)=[C:10](C(O)=O)[C:9]=2[C:19]2[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=2)=[CH:4][CH:3]=1>CCO>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:15]3[C:11]([S:12][CH2:13][CH2:14]3)=[CH:10][C:9]=2[C:19]2[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 10268826HCID 10268826, compound

Product 1

HCID 9814705HCID 9814705, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

5-(4-Fluorophenyl)-6-(4-pyridyl)-2,3-dihydropyrrolo-[2,1-b]-thiazole-7-carboxylic acid (example 11, 120 mg, 0.35 mmol) is heated under argon in an oil bath firstly at 140° C. for 2 h and then at 180° C. for 3 h. After cooling to RT, the brown-red melt cake is digested with a little EtOH. The undissolved, red-brown substance is filtered off with suction, washed with ether and dried: 0.07 g.

Workup

  1. filtrationThe undissolved, red-brown substance is filtered off with suction
  2. washwashed with ether
  3. customdried

Sources & evidence

ORD record
ord-02990801fc564f5884477d361e378979
Source dataset
uspto-grants-2005_03
Patent number
US06867211B2

Reaction notes

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