HCID 22557512, compound → HCID 16228413, compound

HRID 983914Notes

Reaction equation

HRID 983914 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7]([N:9]2[CH2:13][CH2:12][CH2:11][CH:10]2[C:14]([O:16]CC2C=CC=CC=2)=[O:15])=[O:8])=[CH:3][CH:2]=1.[H][H]>C1COCC1.C(O)C.[Pd]>[N:1]1[CH:2]=[CH:3][C:4]([C:7]([N:9]2[CH2:13][CH2:12][CH2:11][CH:10]2[C:14]([OH:16])=[O:15])=[O:8])=[CH:5][CH:6]=1

Participants

6

Reactant 2

HCID 22557512HCID 22557512, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 16228413HCID 16228413, compound

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 702EthanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

Benzyl 1-(pyridine-4-carbonyl)pyrrolidine-2-carboxylate (4.0 g, 11.5 mmol) is dissolved at RT in a mixture of THF and ethanol abs. (1:1, 30 ml), and treated with palladium on active carbon (10%, 0.7 g). Evacuation is then carried out three times and the vacuum is replaced by hydrogen from a balloon.

Sources & evidence

ORD record
ord-c02e018f61d54ebf83faa26b8f0882c8
Source dataset
uspto-grants-2005_03
Patent number
US06867211B2

Reaction notes

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