2-(6-fluoro-1H-indol-3-yl)acetamide → 3-(6-(tert-butoxycarbonyl)-4,5-dihydro-6H-[1,4]diazepino[6,7,1-hi]indol-1-yl)-4-(6-fluoro-1H-indol-3-yl)pyrrole-2,5-dione
Reaction equation
CO[C:3](=[O:26])[C:4]([CH:6]1[N:17]2[C:18]3[C:14]([CH:15]=[CH:16]2)=[CH:13][CH:12]([C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[CH2:11][C:10]=3[CH2:9][N:8]=[CH:7]1)=O.[F:27][C:28]1[CH:36]=[C:35]2[C:31]([C:32]([CH2:37][C:38]([NH2:40])=[O:39])=[CH:33][NH:34]2)=[CH:30][CH:29]=1>>[C:22]([O:21][C:19]([CH:12]1[CH2:11][C:10]2[CH2:9][N:8]=[CH:7][CH:6]([C:4]3[C:3](=[O:26])[NH:40][C:38](=[O:39])[C:37]=3[C:32]3[C:31]4[C:35](=[CH:36][C:28]([F:27])=[CH:29][CH:30]=4)[NH:34][CH:33]=3)[N:17]3[C:18]=2[C:14]([CH:15]=[CH:16]3)=[CH:13]1)=[O:20])([CH3:24])([CH3:23])[CH3:25]Participants
3
Reactant 2
Product 1
Procedure
Beginning with (6-(tert-butoxycarbonyl)-4,5-dihydro-6H-[1,4]diazepino[6,7,1-hi]indol-1-yl)oxoacetic acid methyl ester and 6-fluoroindole-3-acetamide, the title compound was prepared essentially as described in EXAMPLE 133.
Sources & evidence
- ORD record
- ord-5ed671f4bf8f4685a91a031d593a0c84
- Source dataset
- uspto-grants-2005_03
- Patent number
- US06867198B2
Reaction notes
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