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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 983987Generated: October 30, 2026

2-(6-fluoro-1H-indol-3-yl)acetamide → 3-(6-(tert-butoxycarbonyl)-4,5-dihydro-6H-[1,4]diazepino[6,7,1-hi]indol-1-yl)-4-(6-fluoro-1H-indol-3-yl)pyrrole-2,5-dione

https://huagongshe.com/reaction/983987

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(6-fluoro-1H-indol-3-yl)acetamideHCID 21950062—
Reactant(6-(tert-butoxycarbonyl)-4,5-dihydro-6H-[1,4]diazepino[6,7,1-hi]indol-1-yl)oxoacetic acid methyl esterHCID 69743499—
Product3-(6-(tert-butoxycarbonyl)-4,5-dihydro-6H-[1,4]diazepino[6,7,1-hi]indol-1-yl)-4-(6-fluoro-1H-indol-3-yl)pyrrole-2,5-dioneHCID 69742753—

Reaction Steps

Beginning with (6-(tert-butoxycarbonyl)-4,5-dihydro-6H-[1,4]diazepino[6,7,1-hi]indol-1-yl)oxoacetic acid methyl ester and 6-fluoroindole-3-acetamide, the title compound was prepared essentially as described in EXAMPLE 133.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06867198B2
Source datasetuspto-grants-2005_03
ORD IDord-5ed671f4bf8f4685a91a031d593a0c84
Source noteuspto-grants-2005_03