2-(6-fluoro-1H-indol-3-yl)acetamide → 3-(6-Fluoro-1H-indol-3-yl)-4-(4-hydroxylmethyl-5,6-dihydro-4H-pyrrolo[3,2, 1-ij]quinolin-1-yl)pyrrole-2,5-dione

HRID 983997Notes

Reaction equation

HRID 983997 reaction equation
[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH2:11][C:12]([NH2:14])=[O:13])=[CH:7][NH:8]2)=[CH:4][CH:3]=1.C[O:16][C:17](=O)[C:18]([C:20]1[C:30]2=[C:31]3[C:26](=[CH:27][CH:28]=[CH:29]2)[CH2:25][CH2:24][CH:23]([CH2:32][OH:33])[N:22]3[CH:21]=1)=O>>[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:11]3[C:12](=[O:13])[NH:14][C:17](=[O:16])[C:18]=3[C:20]3[C:30]4=[C:31]5[C:26](=[CH:27][CH:28]=[CH:29]4)[CH2:25][CH2:24][CH:23]([CH2:32][OH:33])[N:22]5[CH:21]=3)=[CH:7][NH:8]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 219500622-(6-fluoro-1H-indol-3-yl)acetamideHCID 69742777(4-hydroxymethyl-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)oxoacetic acid methyl ester

Product 1

HCID 225568613-(6-Fluoro-1H-indol-3-yl)-4-(4-hydroxylmethyl-5,6-dihydro-4H-pyrrolo[3,2, 1-ij]quinolin-1-yl)pyrrole-2,5-dione

Procedure

Beginning with 2-(6-fluoro-1H-indol-3-yl)acetamide and (4-hydroxymethyl-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)oxoacetic acid methyl ester, the title compound was prepared essentially as described in Example 1.

Sources & evidence

ORD record
ord-54271e7ed7b04dd192a7b6964aff59a2
Source dataset
uspto-grants-2005_03
Patent number
US06867198B2

Reaction notes

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