反应详情

A 50 mg portion of 6-amino-5-chloro-2-(4-methyl-1-piperazinyl)benzoxazole was dissolved in 5 ml of DMF, and the solution, while stirring at room temperature, was mixed with 135 mg of allyl bromide and stirred for additional 2 hours. Thereafter, the solvent was evaporated under a reduced pressure and the thus obtained mixture was purified by an LH-20 gel column chromatography (chloroform:methanol=1:1) to obtain the title compound (15 mg) in light yellow color.

1. stirringstirred for additional 2 hours
2. customThereafter, the solvent was evaporated under a reduced pressure
3. customthe thus obtained mixture was purified by an LH-20 gel column chromatography (chloroform:methanol=1:1)