5-Dimethylthiocarbamoyloxy-benzofuran-2-carboxylic acid methyl ester → Methyl 5-hydroxybenzofuran-2-carboxylate

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Reaction Steps

A solution of 5-dimethylthiocarbamoyloxy-benzofuran-2-carboxylic acid methyl ester (1.3 g, 4.7 mmol) in 25 mL diphenyl ether was heated at reflux for 2.5 hours. The reaction mixture was then cooled and the resulting precipitate collected. Purification by flash column chromatography (gradient elution: 100% hexanes to 45% EtOAc/hexanes), gave the title compound (0.58 g, 45%) as a brown solid.

Provenance & Evidence