反应详情

A solution of 5-dimethylthiocarbamoyloxy-benzofuran-2-carboxylic acid methyl ester (1.3 g, 4.7 mmol) in 25 mL diphenyl ether was heated at reflux for 2.5 hours. The reaction mixture was then cooled and the resulting precipitate collected. Purification by flash column chromatography (gradient elution: 100% hexanes to 45% EtOAc/hexanes), gave the title compound (0.58 g, 45%) as a brown solid.

1. temperatureat reflux for 2.5 hours
2. temperatureThe reaction mixture was then cooled
3. customthe resulting precipitate collected
4. customPurification
5. washby flash column chromatography (gradient elution: 100% hexanes to 45% EtOAc/hexanes)