{6-[4-Methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethylsulfanyl]-3,4-dihydro-2H-quinolin-1-yl}-acetic acid methyl ester → (6-Mercapto-3,4-dihydro-2H-quinolin-1-yl)-acetic acid methyl ester

HRID 984111Notes

Reaction equation

HRID 984111 reaction equation
COC(C1CC2C(=CC=C(S)C=2)C1)=O.[CH3:15][O:16][C:17](=[O:47])[CH2:18][N:19]1[C:28]2[C:23](=[CH:24][C:25]([S:29]CC3SC(C4C=CC(C(F)(F)F)=CC=4)=NC=3C)=[CH:26][CH:27]=2)[CH2:22][CH2:21][CH2:20]1>>[CH3:15][O:16][C:17](=[O:47])[CH2:18][N:19]1[C:28]2[C:23](=[CH:24][C:25]([SH:29])=[CH:26][CH:27]=2)[CH2:22][CH2:21][CH2:20]1

Participants

3

Reactant 2

HCID 20765978{6-[4-Methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethylsulfanyl]-3,4-dihydro-2H-quinolin-1-yl}-acetic acid methyl ester2×HCID 207660125-Mercapto-Indan-2-Carboxylic Acid Methyl Ester

Product 1

HCID 20765991(6-Mercapto-3,4-dihydro-2H-quinolin-1-yl)-acetic acid methyl ester

Procedure

11C was prepared analogously to compound 1C. Used as unpurified oil. MS: 238 (M+1)+. Preparation of {6-[4-Methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethylsulfanyl]-3,4-dihydro-2H-quinolin-1-yl}-acetic acid methyl ester (Compound 11D)

Sources & evidence

ORD record
ord-5b14d30734b8450d9e713caa39591935
Source dataset
uspto-grants-2005_03
Patent number
US06867224B2

Reaction notes

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