化工社化工社 化学情報印刷レポート · 研究参考用
Sodium Cyanide → Chroman-3-yl-acetonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Cyanide | HCID 8929 | — |
| 反応物 | Toluene-4-sulfonic acid Chroman-3-ylmethyl ester | HCID 11267124 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | Chroman-3-yl-acetonitrile | HCID 14838407 | 126.4% |
反応手順
Compound 18B (1.25 g), NaCN (0.15 g) in 25 mL of DMF, were heated to 60° C. for 12 h. The solvent was removed, the reaction mixture was mixed with water (125 mL) and ether (125 mL). The ether layer was separated, washed with water, brine, dried (MgSO4), concentrated to afford compound 18C (0.67 g). mp 54-55.5° C.; MS: 174 (M+1)+. Preparation of 3-Cyanomethyl-chroman-6-sulfonyl chloride (Compound 18D)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06867224B2 |
| 出典データセット | uspto-grants-2005_03 |
| ORD ID | ord-b46e117ef1f645828dbbb57f7129736b |
| 出典メモ | uspto-grants-2005_03 |