反应详情

Compound 18B (1.25 g), NaCN (0.15 g) in 25 mL of DMF, were heated to 60° C. for 12 h. The solvent was removed, the reaction mixture was mixed with water (125 mL) and ether (125 mL). The ether layer was separated, washed with water, brine, dried (MgSO4), concentrated to afford compound 18C (0.67 g). mp 54-55.5° C.; MS: 174 (M+1)+. Preparation of 3-Cyanomethyl-chroman-6-sulfonyl chloride (Compound 18D)

1. customThe solvent was removed
2. additionthe reaction mixture was mixed with water (125 mL) and ether (125 mL)
3. customThe ether layer was separated
4. washwashed with water, brine
5. dry with materialdried (MgSO4)
6. concentrationconcentrated