5-Mercapto-Indan-2-Carboxylic Acid Methyl Ester → (5-Mercapto-6-methoxy-indan-1-yl)-acetic acid ethyl ester

HRID 984125Notes

Reaction equation

HRID 984125 reaction equation
[CH3:1]OC(C1CC2C(=CC=C(S)C=2)C1)=O.[CH3:15][O:16][C:17](=[O:48])[CH2:18][CH:19]1[C:27]2[C:22](=[CH:23][C:24]([S:30]CC3SC(C4C=CC(C(F)(F)F)=CC=4)=NC=3C)=[C:25]([O:28][CH3:29])[CH:26]=2)[CH2:21][CH2:20]1>>[CH2:15]([O:16][C:17](=[O:48])[CH2:18][CH:19]1[C:27]2[C:22](=[CH:23][C:24]([SH:30])=[C:25]([O:28][CH3:29])[CH:26]=2)[CH2:21][CH2:20]1)[CH3:1]

Participants

3

Reactant 2

HCID 207660125-Mercapto-Indan-2-Carboxylic Acid Methyl EsterHCID 69590840{6-Methoxy-5-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethylsulfanyl]-indan-1-yl}-acetic acid methyl ester2×

Product 1

HCID 20765962(5-Mercapto-6-methoxy-indan-1-yl)-acetic acid ethyl ester

Procedure

19C was prepared analogously to compound 1C. Used as unpurified oil. MS: 267 (M+1)+. Preparation of {6-Methoxy-5-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethylsulfanyl]-indan-1-yl}-acetic acid methyl ester (Compound 19D)

Sources & evidence

ORD record
ord-7131c44441034852ac9910532c106e0f
Source dataset
uspto-grants-2005_03
Patent number
US06867224B2

Reaction notes

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