反应详情

4-hydroxymethyl-2-(3,4,5-trimethoxyphenyl)pyridine(19.18 g) was dissolved in chloroform (100 mL), and to the solution thinly chloride (10.2 mL) was added at 0° C. After 30 minutes, the mixture was warmed to room temperature and stirred for 4 hours. The reaction mixture was washed with aqaueous saturated sodium hydrogendcarbonate and brine, dried over anhydrous sodium sulfate and evaporated. The residue was then recrystallized from ethyl acetate-hexane to give the title compound as pale yellow crystalline powder.

1. washThe reaction mixture was washed with aqaueous saturated sodium hydrogendcarbonate and brine
2. dry with materialdried over anhydrous sodium sulfate
3. customevaporated
4. customThe residue was then recrystallized from ethyl acetate-hexane